2. Signaling Pathways
  3. Apoptosis
  4. RIP kinase

RIP kinase

Receptor-interacting protein kinases; RIPK

RIP kinase

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Receptor-interacting protein (RIP) kinases are a group of threonine/serine protein kinases with a relatively conserved kinase domain but distinct non-kinase regions. There are seven members of the RIPK family, RIPK1-7, some of which have emerged as critical effectors of immunity to infection with a diverse array of bacterial, viral, and protozoal pathogens.

RIP kinases are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key mediators of intracellular signal transduction including inflammation, autophagy and programmed cell death, and are thus essential for the early control of many diverse pathogenic organisms.

RIP kinase Isoform Specific Products:

RIP kinase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-103028AR
    GSK963 (Standard)
    		Inhibitor
    GSK963 (Standard) is the analytical standard of GSK963 (HY-103028A). This product is intended for research and analytical applications. GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro.
    GSK963 (Standard)
  • HY-151542
    MLKL-IN-4
    		Inhibitor
    MLKL-IN-4 (compound 56) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-4 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 82 nM. MLKL-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    MLKL-IN-4
  • HY-N0546R
    Ligustroflavone (Standard)
    		Inhibitor
    Ligustroflavone (Standard) is the analytical standard of Ligustroflavone (HY-N0546). This product is intended for research and analytical applications. Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis.
    Ligustroflavone (Standard)
  • HY-104021R
    GSK840 (Standard)
    		Inhibitor
    GSK840 (Standard) is the analytical standard of GSK840 (HY-104021). This product is intended for research and analytical applications. GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM.
    GSK840 (Standard)
  • HY-101760R
    GSK2982772 (Standard)
    		Inhibitor
    GSK2982772 (Standard) is the analytical standard of GSK2982772 (HY-101760). This product is intended for research and analytical applications. GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
    GSK2982772 (Standard)
  • HY-175374
    RIPK1 ligand-Linker Conjugate-1
    		Inhibitor
    RIPK1 ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for RIPK1 (HY-175371) and a PROTAC linker (HY-175373), which recruits E3 ligases. RIPK1 ligand-Linker Conjugate-1 can be used for synthesis of PROTAC RIPK1 Degrader-1 (HY-175370).
    RIPK1 ligand-Linker Conjugate-1
  • HY-14622AR
    Necrostatin 2 racemate (Standard)
    		Inhibitor
    Necrostatin 2 (racemate) (Standard) is the analytical standard of Necrostatin 2 (racemate). This product is intended for research and analytical applications. Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect.
    Necrostatin 2 racemate (Standard)
  • HY-100131R
    GSK481 (Standard)
    		Inhibitor
    GSK481 (Standard) is the analytical standard of GSK481 (HY-100131). This product is intended for research and analytical applications. GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC50 of 1.3 nM, which inhibits Ser166 phosphorylation in wild-type human RIP1 (IC50=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC50 of 10 nM.
    GSK481 (Standard)
  • HY-162880
    RIPK1-IN-24
    		Inhibitor
    RIPK1-IN-24 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 value of 1.3 μM. RIPK1-IN-24 can be used for research on inflammatory diseases.
    RIPK1-IN-24
  • HY-101032R
    RIPA-56 (Standard)
    		Inhibitor
    RIPA-56 (Standard) is the analytical standard of RIPA-56 (HY-101032). This product is intended for research and analytical applications. RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome.
    RIPA-56 (Standard)
  • HY-168770
    Cl-Necrostatin-1
    		Inhibitor
    Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases.
    Cl-Necrostatin-1
  • HY-107978R
    RIPK-IN-4 (Standard)
    		Inhibitor
    RIPK-IN-4 (Standard) is the analytical standard of RIPK-IN-4 (HY-107978). This product is intended for research and analytical applications. RIPK-IN-4 is a selective RIPK2 inhibitor with an IC50 value of 3 nM. RIPK-IN-4 can be used for the research of inflammatory diseases.
    RIPK-IN-4 (Standard)
  • HY-101872AR
    GSK-872 hydrochloride (Standard)
    		Inhibitor
    GSK-872 hydrochloride (Standard) is the analytical standard of GSK-872 hydrochloride (HY-101872A). This product is intended for research and analytical applications. GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
    GSK-872 hydrochloride (Standard)
  • HY-100339R
    GSK583 (Standard)
    		Inhibitor
    GSK583 (Standard) is the analytical standard of GSK583 (HY-100339). This product is intended for research and analytical applications. GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200 nM.
    GSK583 (Standard)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
RIP kinase Isoform Comparison

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